|
嚴宏洋
博士
 |
| |
感 覺 神 經 生 理 研 究 室 |
|
辦公室電話 |
(03) 9880544 分機 18 |
|
實驗室電話 |
(03) 9880544 分機 26 |
|
傳真 |
(03) 9871035 |
| |
實驗室位置 |
中研院臨海研究站B108 |
| |
電子郵件 |
hyyan@gate.sinica.edu.tw |
|
|
|
本人從2010今日起在外國訪問,要到2月8日才會回到實驗室。有急事連絡時,請與我的助理傅雯君小姐連絡
03-988-0544 ext. 26
I am currently on an overseas assignment and won't be back
to my lab
until February 8. If you have any urgent need, please
contact my
assistant, Ms. W. C. Fu at 886-3-988-0544 ext. 26.
Best wishes.
Hong Young Yan |
| |
|
中國童子軍台北市22團 |
|
[ 學歷 ] |
|
美國德州大學奧斯汀分校 |
動物系 |
博士 |
1986 |
|
國立台灣大學 |
海洋研究所 |
碩士 |
1979 |
|
國立台灣大學 |
動物學系 |
學士 |
1974 |
|
[ 經歷 ] |
|
中央研究院 |
臨海研究站 |
研究員 |
2004/09- 迄今 |
|
University
of Kentucky |
生物系 |
副教授 |
1999/08-2004/08 |
|
University
of Kentucky |
生物系 |
助理教授 |
1993/08-1999/07 |
|
[研究] |
|
|
|
[實驗室簡介] |
本實驗室係建立於2004年9月。目前的成員有:實驗室主持人嚴宏洋博士;五位研究助理:林生華、鍾文松、邵奕達、余欣怡、李伍鎔。二位清華大學研究生:李懿欣
(博士班),張家豪(碩士班)(以上二位都是與清華大學焦傳金教授共同指導)。
|
| |
|
|
[研究主題] |
水生動物的感官神經生理學的基礎與應用研究 |
| |
|
|
[研究設備] |
1.
聽覺腦幹誘導電位
(ABR)
[介紹]
2.
顯微分光光譜儀
(MSP) [介紹]
3.
眼波圖(ERG)
[介紹] |
| |
|
|
[目前研究計畫]
[詳細] |
1.
香魚老化過程生理的變化與基因的表現
[介紹]
2.
聽覺神經生理在核能電廠吸排水口驅魚的應用
[介紹]
3.
魚類視覺生理與生態的研究
[介紹]
4.
魚類聽覺能力形成機制的研究 |
|
[實驗室人員] |
博士班:
李懿欣
碩士班:
張家豪
大學部:
助 理: 林生華 鍾文松
邵奕達
余欣怡
李伍鎔 |
|
|
|
<- 按圖放大 |
| |
[實驗室雜記] |
| |
|
[著作] |
| [近五年期刊] [所有已發表著作]
[研討會論文]
[技術報告及專書]
[專利及其它] |
| 1.
|
2005. Lovell, J. M.,
Findlay
, M. M., Moate, R. M., Yan, H. Y. The hearing abilities of
the prawn Palemon serratus. Comparative
Biochemistry and Physiology A. 140:89-100.
[Full
Text]
|
| 2.
|
2005. Simpson, S. D., Yan, H.
Y., Wittenrich, M. L., Meekan, M. G. Response of embryonic
coral reef fishes (Pomacentridae: Amphiprion spp.) to
noise. Marine Ecology Progress Series
287:201-208.
[Full
Text]
|
| 3.
|
2004. Yan, H. Y.
Harvesting drugs from the seas and how
Taiwan
could contribute to this effort. Changhua
Journal of Medicine 9: 1-6.
[Full
Text]
|
| 4.
|
2004.
Scholik, A. R., Lee, U. S., Chow, C. K., Yan, H. Y.
Dietary vitamin E protects the fathead minnow, Pimephales
promelas, against noise exposure. Comparative
Biochemistry and Physiology C. 137: 313-323.
[Full
Text] |
| 5.
|
2003.
Casper, B. M., Lobel, P. S., Yan, H. Y. The hearing
sensitivity pf the little skate, Raja erinacea: a comparison
of two methods. Environmental Biology of Fishes.
68: 371-379.
[Full
Text] |
| 6.
|
2003.
Lugli, M., Yan, H. Y. Fine, M. L. Acoustic
communication in two freshwater gobies: the relationship
between ambient noise, hearing thresholds and sound
spectrum. Journal of Comparative Physiology A.
189: 309-320.
[Full
Text] |
| 7.
|
2003.
Akamatsu, T., Nanami, A., Yan, H. Y. Spotlined sardin
Sardinops melanostictus listens to 1-kHz sound by
using its gas bladder. Fisheries Science 69:
348-354.
[Full
Text] |
| 8.
|
2002.
Akamatsu, T. Okumura, T. Novarini, N.,Yan, H. Y.
Empirical refinements applicable to the recording of fish
sounds in small tanks. Journal of Acoustical Society
of America 112: 3073-3082.
[Full
Text] |
| 9.
|
2002.
Scholik, A. R., Yan, H. Y. The effects of noise on
the auditory sensitivity of the bluegill sunfish, Lepomis
macrochirus. Comparative Biochemistry and
Physiology A 133: 43-52.
[Full
Text] |
| 10.
|
2002.
Chen, L. S., Yan, H. Y. The relative distribution of
larval otoliths as a means of larval fish identification.
Zoological Studies 41 :144-152.
[Full
Text] |
| 11.
|
2002.
Sparkes, T. C., Prater. C., Akamatsu, T., Yan, H.
Y. Acoustic signals and aggressive conflicts in the
skunk loach (Botia morleti): Integrating sensory and
behavioral approaches. Bioacoustics 12: 257-259.
[Full
Text] |
| 12.
|
2002.
Okumura, T., Akamatsu, T., Yan, H. Y. Analyses of
small tank acoustics: An empirical and theoretical
approaches. Bioacoustics 12: 330-332.
[Full
Text] |
| 13.
|
2002. Yan, H. Y. The use of acoustically evoked
potentials for the study of enhanced hearing in fishes.
Bioacoustics 12: 325-328.
[Full
Text] |
| 14.
|
2002.
Scholik, A. R., Yan, H. Y. Effects of noise on
auditory sensitivity of fishes. Bioacoustics
12: 186-188.
[Full
Text] |
| 15.
|
2002.
Ripley, J. L., Lobel, P. S., Yan, H. Y. Correlation
of sound production with hearing sensitivity in the Lake
Malawi cichlid, Tranmitichromis intermedius.
Bioacoustics 12: 238-240.
[Full
Text] |
| 16.
|
2002.
Scholik, A. R., Yan, H. Y. Effects of boat engine
noise on the auditory sensitivity of the fathead minnow (Pimephales
promeleas). Environmental Biology of Fishes
63(2): 203-209.
[Full
Text] |
| 17.
|
2001.
Yan, H. Y. A non-invasive electrophysiological study on
the enhancement of hearing ability in fishes.
Proceedings of Institute of Acoustics, United Kingdom
23(2): 15-25.
[Full Text] |
| 18.
|
2001.
Scholik, A. R., Yan, H. Y. Effects of underwater
noise on auditory physiology of fishes. Proceedings of
Institute of Acoustics, United Kingdom 23(2): 27-36.
[Full Text] |
| 19.
|
2001.
Jeng, L. H., Yan, H. Y. Cross-disciplinary
information research: a case in bio-acoustics.
Proceedings of Institute Acoustics, United Kingdom
23(2): 101-102.
[Full Text] |
| 20. |
2001.
Scholik, A. R., Yan, H. Y. Effects of underwater
noise on auditory sensitivity of acyprinid fish.
Hearing Res. 152: 17-24.
[Full Text] |
| |
| [研討會論文] |
| 1.
|
2005. Yan, H. Y.
Analyses of characteristics of underwater noise generated by
aerators and its possible physiological impacts on fish. The
seventh Indo-Pacific Fish Conference, Taipei, Taiwan.
(Abstract) p.135 |
| |
| [技術報告及專書] |
| 1.
|
Yan, H. Y. The role of gas-holding structures in fish
hearing: an acoustically evoked potentials approach. In
"Senses of Fishes" (eds.) G. von der Emede and J. Mogdans.
Narosa Publishing House. pp. 189-209.
[Full Text] |
象鼻魚放電機制 像人類心跳
【大紀元1月3日訊】〔自由時報記者郭怡君╱台北報導〕台灣中央研究院動物研究所臨海研究站最近引進原產於西非的象鼻魚進行神經生理研究,發現此種會放弱電的熱帶魚,腦部控制放電的節拍器在細胞膜構造和物理機制上,都和人類心臟控制心跳緩急的節拍器相當類似,可望作為「心律不整」病症的模式動物,以供未來疾病治療參考。
中研院臨海研究站神經生理研究室研究員嚴宏洋指出,象鼻魚是夜行性的熱帶魚,在視覺退化下,象鼻魚從肌肉細胞演化出可產生電流的電細胞,能形成隨個體移動的電場,從電場被外界物體干擾的位置和強度,來判別方向和食物所在。
嚴宏洋指出,象鼻魚一孵化出生後便有放電本領,身上約有五千個電細胞全都集中在魚尾的柄部,為了維持體外強度約為千分之二伏特的電場,全部的電細胞必須靠腦部的節拍器控制同時啟動、關閉再啟動,才能持續產生電流維持電場的存在,而人類心跳控制也需要心臟傳導系統的開關統一,否則就會產生心律不整。
目前研究心律不整的模式動物以老鼠和兔子為主,但研究時往往必須將心臟打開才能看清楚,每次實驗都會造成動物犧牲,嚴宏洋指出,象鼻魚的腦部離體表很近,在良好的實驗環境控制下,能將魚的頭皮打開觀察牠的腦部構造和反應,實驗後再用特殊化合物滴在頭皮上,遇水即會自動凝結,無須縫合也能保住實驗魚的性命。
嚴宏洋指出,經由藥物處理,可讓象鼻魚產生類似人類心律不整的不規則放電症狀,該實驗室將仔細研究牠腦部節拍器細胞膜上的離子管道,及神經生物、生物化學、基因調控機制,可望提供治療人類心律不整疾病所需的參考資料。
|